Case not Clear

Letters to the editor regarding the article Whole-Body Pain in a Case of a Phosphaturic Tumor by Konstantinos Anagnostakos, Ismail Sahan and Winfried Häuser in issue 26/2024

The authors of this clinical snapshot reported on a phosphaturic tumor on the left foot, which was excised (1).

Simultaneously the authors found treatment-resistant hypophosphatemia and a significantly elevated serum fibroblast growth factor (FGF)23 level. To me, the histology assessment is not clear because histology presents a “phosphaturic” mesenchymal tumor. “Phosphaturic” describes a loss of phosphate but not a histology result. Based on the findings, X-chromosomal hypophosphatemia may have a role, which is vanishingly rare. Was this investigated more closely? Was the serum klotho concentration measured? The case seems not clear.

DOI: 10.3238/arztebl.m2025.0047

Prof. Dr. Bittmann M.A.

Pediatrician, Gronau, Germany

References

1. Anagnostakos K, Sahan I, Häuser W: Whole-body pain in a case of a phosphaturic tumor. Dtsch Arztebl Int 2024; 121: 890